Brandy & Mr. Whiskers is an animated television series that is televised in the United States by Disney Channel.

Brandy & Mr. Whiskers is an animated television series that is televised in the United States by Disney Channel. The series' first episode was shown in August of 2004 and Toon Disney in January 2006.Production of season one of Brandy and Mr. Whiskers began in 2003 and ended in 2004, all 21 episodes concluded airing in 2005. Production for Season two began in 2004 and ended in 2005. Since the ratings of the show were falling fast, Season two would be the last season and production was stopped in 2005, and the remaining episodes aired from February to August 2006. Some Season two episodes include a "Good-Bye, Folks" kind of ending with Brandy and Mr. Whiskers which is pretty familiar with The Ren and Stimpy Show's Season 1 and 2's endings with Ren saying good-bye to the kids and Stimpy still wanting to stick around.

Brandy Harrington (age 15) (voiced by Kaley Cuoco): Brandy is a female anthropomorphic dog from an opulent family she constantly brags about. Because of her social origins, she is accustomed to the finer things in life. She is intelligent, cute and full of herself. Her character is modeled after Paris Hilton, from the Simple Life series in appearance and with stereotypical condescending attitudes of opulent people. While on her way to a five-star spa, a mishap with Mr. Whiskers caused the two of them to fall straight into the Amazon Rainforest, most likely a door blowout on the aircraft. This theory is proven by two things, the very first being that their falling out of the aircraft is featured on the beginning clip. The second being the door used on the treehouse is an aircraft exit door. A strange thing happens, the door appears to release pressure when opened (usually by Brandy storming in). Brandy prefers to make the most out of any situation and she attempts to improve her own standing by mistreating and abusing the kindness of her friends, though she does care for her friends at times. However, she is always on the lookout for escape opportunities and she wants nothing more than to be able to get back home to her family in Florida.
Mr. Whiskers (age 7) (voiced by Charles Adler and later Billy West): Mr. Whiskers is a white rabbit who hasn't had very many friends during his lifetime. On an initial observance of Mr. Whiskers, one would perceive him as silly, sloppy, stinky, gross, batty, insane, hyperactive and overall annoying. After further observance of Mr. Whiskers one would notice that he is highly intelligent with a large vocabulary, which is exhibited at special moments. He is also very loving and caring, but he can be clumsy and clueless at times although he is arrogant and naughty. When he first met Brandy he was on his way to a zoo in Paraguay, though he soon made a mistake that caused the two of them to fall into the Amazon Rainforest. While Brandy often is embarrassed by his antics, Whiskers does his best to help out Brandy and he does cherish his friendship with her, though she doesn't always feel the same way. Mr. Whiskers' other best friend is Ed, a river otter whom he often spends his time with.